Auto-Pilot checks your lineup every 12 hours most days (except for Tuesdays), and multiple times in the hour before games start. The Swap Out Inactives mode starts running on Thursdays as player statuses are updated.
Please note: Each time Auto-Pilot checks your lineup, it first checks if your optimal lineup has changed since the last time we notified you (or submitted a lineup for you). If your optimal lineup hasn’t changed, Auto-Pilot won’t take any further action. This is designed to avoid sending you duplicate emails or overriding any manual changes you’ve made to your lineup in the meantime.